Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC031
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-10-20 15:02
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old patient tblMadopar 250mg 1/2+1/4+1/2+1/4 caps Madopar HBS 125mg 1x1

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 7 individuals with a value less than 0.53 were subsequently diagnosed with PD. That is, 16.67% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.53 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 5, 'TN': 5, 'TP': 37, 'FP': 25}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 20, 'TN': 17, 'TP': 22, 'FP': 13}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 38, 'TN': 29, 'TP': 4, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 6, 'TP': 33, 'FP': 24}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 7.328
timePerCircleCoV 0.158408
timePerCircleSlope -0.0316925
meanError 2.10431
tremorFreq 6.73828
tremorRelPower 38.5678
tremorGyroAmpMean 0.0876686
tremorGyroAmpSlope -0.000441249
tremorGyroAmpCoV 0.384374
tremorCoordAmpMean 0.176902
tremorCoordAmpSlope -0.00207225
tremorCoordAmpCoV 0.500486
tremorAccAmpMean 0.16226
tremorAccAmpSlope -0.00432722
tremorAccAmpCoV 0.512842
tremorPcRelVar 0.846443
tremorPcX -0.364681
tremorPcY 0.931133

Circle Segment 1

Duration 8.96 s, Accuracy Estimate 1.609 (lower is better)

Circle Segment 2

Duration 8.36 s, Accuracy Estimate 1.912 (lower is better)

Circle Segment 3

Duration 6.76 s, Accuracy Estimate 1.776 (lower is better)

Circle Segment 4

Duration 6.92 s, Accuracy Estimate 2.479 (lower is better)

Circle Segment 5

Duration 7.08 s, Accuracy Estimate 2.3 (lower is better)

Circle Segment 6

Duration 7.44 s, Accuracy Estimate 1.699 (lower is better)

Circle Segment 7

Duration 8.32 s, Accuracy Estimate 1.729 (lower is better)

Circle Segment 8

Duration 7.8 s, Accuracy Estimate 1.854 (lower is better)

Circle Segment 9

Duration 6.84 s, Accuracy Estimate 1.646 (lower is better)

Circle Segment 10

Duration 4.8 s, Accuracy Estimate 4.039 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 24.884
timePerSpiralCoV 0.193831
timePerSpiralSlope 0.0122264
meanError 2.69225
tremorFreq 6.64062
tremorRelPower 38.6192
tremorGyroAmpMean 0.0728221
tremorGyroAmpSlope 0.00237701
tremorGyroAmpCoV 0.49441
tremorCoordAmpMean 0.142444
tremorCoordAmpSlope 0.00129245
tremorCoordAmpCoV 0.418976
tremorAccAmpMean 0.118927
tremorAccAmpSlope 0.000667586
tremorAccAmpCoV 0.368371
tremorPcRelVar 0.756638
tremorPcX 0.437061
tremorPcY -0.899432

Spiral Segment 1

Duration 31.48 s, Accuracy Estimate 2.283 (lower is better)

Spiral Segment 2

Duration 26.72 s, Accuracy Estimate 2.256 (lower is better)

Spiral Segment 3

Duration 15.72 s, Accuracy Estimate 2.755 (lower is better)

Spiral Segment 4

Duration 19.4 s, Accuracy Estimate 2.619 (lower is better)

Spiral Segment 5

Duration 21.28 s, Accuracy Estimate 2.804 (lower is better)

Spiral Segment 6

Duration 24.88 s, Accuracy Estimate 2.802 (lower is better)

Spiral Segment 7

Duration 29.28 s, Accuracy Estimate 2.969 (lower is better)

Spiral Segment 8

Duration 24.68 s, Accuracy Estimate 2.389 (lower is better)

Spiral Segment 9

Duration 28.04 s, Accuracy Estimate 2.954 (lower is better)

Spiral Segment 10

Duration 27.36 s, Accuracy Estimate 3.091 (lower is better)

Elel

eDurationMean 0.613784
eDurationStd 0.127161
eDurationStdnorm 0.207176
eDurationMedian 0.6
eDurationQuartdelta 0.16125
eDurationQuartdeltanorm 0.26875
eDurationKurt 3.80697
eDurationTrenddiff -0.125
eDurationTrendratio 0.809886
eWidthMean 3.42146
eWidthStd 0.984472
eWidthStdnorm 0.287735
eWidthMedian 3.276
eWidthQuartdelta 1.08225
eWidthQuartdeltanorm 0.330357
eWidthKurt 3.38987
eWidthTrenddiff 0.0585
eWidthTrendratio 1.01852
eHeightMean 7.87062
eHeightStd 1.21046
eHeightStdnorm 0.153795
eHeightMedian 7.605
eHeightQuartdelta 1.6965
eHeightQuartdeltanorm 0.223077
eHeightKurt 2.49466
eHeightTrenddiff -0.351
eHeightTrendratio 0.954198
eAspectMean 0.431397
eAspectStd 0.0866899
eAspectStdnorm 0.200951
eAspectMedian 0.42623
eAspectQuartdelta 0.117227
eAspectQuartdeltanorm 0.275033
eAspectKurt 3.51232
eAspectTrenddiff 0.00230418
eAspectTrendratio 1.00545
eSlantMean 0.139573
eSlantStd 0.0764248
eSlantStdnorm 0.547562
eSlantMedian 0.146341
eSlantQuartdelta 0.0955909
eSlantQuartdeltanorm 0.653205
eSlantKurt 3.60611
eSlantTrenddiff 0.027313
eRtopMean 0.834164
eRtopStd 0.102038
eRtopStdnorm 0.122324
eRtopMedian 0.846154
eRtopQuartdelta 0.161938
eRtopQuartdeltanorm 0.191381
eRtopKurt 2.15896
eRtopTrenddiff 0.0251012
eRbotMean 0.515145
eRbotStd 0.15603
eRbotStdnorm 0.302885
eRbotMedian 0.516129
eRbotQuartdelta 0.169247
eRbotQuartdeltanorm 0.327915
eRbotKurt 4.2257
eRbotTrenddiff 0.0936161
eRrightMean 0.913907
eRrightStd 0.0742787
eRrightStdnorm 0.081276
eRrightMedian 0.929577
eRrightQuartdelta 0.12015
eRrightQuartdeltanorm 0.129252
eRrightKurt 2.20282
eRrightTrenddiff 0.0171682
eRleftMean 0.237797
eRleftStd 0.0975376
eRleftStdnorm 0.410172
eRleftMedian 0.231707
eRleftQuartdelta 0.150665
eRleftQuartdeltanorm 0.65024
eRleftKurt 2.02498
eRleftTrenddiff -0.0632337
lDurationMean 0.7825
lDurationStd 0.159742
lDurationStdnorm 0.204143
lDurationMedian 0.7425
lDurationQuartdelta 0.19
lDurationQuartdeltanorm 0.255892
lDurationKurt 7.48282
lDurationTrenddiff -0.165
lDurationTrendratio 0.79878
lWidthMean 5.42379
lWidthStd 0.891353
lWidthStdnorm 0.164342
lWidthMedian 5.382
lWidthQuartdelta 1.287
lWidthQuartdeltanorm 0.23913
lWidthKurt 3.4925
lWidthTrenddiff 0.468
lWidthTrendratio 1.09091
lHeightMean 16.6112
lHeightStd 3.37039
lHeightStdnorm 0.202898
lHeightMedian 15.8535
lHeightQuartdelta 3.627
lHeightQuartdeltanorm 0.228782
lHeightKurt 4.96159
lHeightTrenddiff 1.17
lHeightTrendratio 1.07634
lAspectMean 0.332751
lAspectStd 0.0562662
lAspectStdnorm 0.169094
lAspectMedian 0.330121
lAspectQuartdelta 0.0706272
lAspectQuartdeltanorm 0.213943
lAspectKurt 3.06574
lAspectTrenddiff -0.00678864
lAspectTrendratio 0.979785
lSlantMean 0.143186
lSlantStd 0.0699843
lSlantStdnorm 0.488765
lSlantMedian 0.148866
lSlantQuartdelta 0.0997984
lSlantQuartdeltanorm 0.67039
lSlantKurt 2.44111
lSlantTrenddiff -0.010816
lRtopMean 0.869056
lRtopStd 0.0832044
lRtopStdnorm 0.0957411
lRtopMedian 0.876276
lRtopQuartdelta 0.138254
lRtopQuartdeltanorm 0.157774
lRtopKurt 2.16784
lRtopTrenddiff -0.024024
lRbotMean 0.445334
lRbotStd 0.155574
lRbotStdnorm 0.349342
lRbotMedian 0.395591
lRbotQuartdelta 0.219621
lRbotQuartdeltanorm 0.555172
lRbotKurt 2.77294
lRbotTrenddiff -0.0522876
lRrightMean 0.93307
lRrightStd 0.0649609
lRrightStdnorm 0.0696207
lRrightMedian 0.95122
lRrightQuartdelta 0.0896628
lRrightQuartdeltanorm 0.0942609
lRrightKurt 2.60293
lRrightTrenddiff -0.0124939
lRleftMean 0.192275
lRleftStd 0.0576211
lRleftStdnorm 0.29968
lRleftMedian 0.193145
lRleftQuartdelta 0.0656212
lRleftQuartdeltanorm 0.33975
lRleftKurt 2.80082
lRleftTrenddiff -0.0267814

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.678639
sumTouchScores 12.2155
meanMovementTime 0.995
numTouches 18
undershootPercentage 0
overshootPercentage 44.4444

FITTS Long Modified

meanTouchScore 0.70134
sumTouchScores 10.5201
meanMovementTime 1.17393
numTouches 15
undershootPercentage 6.66667
overshootPercentage 33.3333

ZigZag

numZigzags 6
timePerZigzagMean 25.2467
timePerZigzagCoV 0.409664
timePerZigzagSlope 0.0477574
meanError 3.51635
tremorFreq 6.34766
tremorRelPower 36.9662
tremorGyroAmpMean 0.127377
tremorGyroAmpSlope 0.0012825
tremorGyroAmpCoV 0.5194
tremorCoordAmpMean 0.204139
tremorCoordAmpSlope -0.000374454
tremorCoordAmpCoV 0.399549
tremorAccAmpMean 0.180333
tremorAccAmpSlope -0.000696486
tremorAccAmpCoV 0.369779
tremorPcRelVar 0.768685
tremorPcX 0.177734
tremorPcY 0.984079

ZigZag Segment 1

Duration 19.92 s, Accuracy Estimate 2.962 (lower is better)

ZigZag Segment 2

Duration 19.44 s, Accuracy Estimate 4.277 (lower is better)

ZigZag Segment 3

Duration 21.0 s, Accuracy Estimate 3.352 (lower is better)

ZigZag Segment 4

Duration 45.84 s, Accuracy Estimate 4.614 (lower is better)

ZigZag Segment 5

Duration 25.56 s, Accuracy Estimate 2.678 (lower is better)

ZigZag Segment 6

Duration 19.72 s, Accuracy Estimate 3.216 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 26.344
timePerZigzagCoV 0.120367
timePerZigzagSlope -0.0440328
zigzagHeightMean 78.9398
zigzagHeightCoV 0.0669208
zigzagHeightSlope 0.0292731
meanError 0.0588687
tremorFreq 6.73828
tremorRelPower 37.1646
tremorGyroAmpMean 0.145952
tremorGyroAmpSlope 0.00150843
tremorGyroAmpCoV 0.404263
tremorCoordAmpMean 0.208396
tremorCoordAmpSlope 0.00136896
tremorCoordAmpCoV 0.4359
tremorAccAmpMean 0.174483
tremorAccAmpSlope 0.00102687
tremorAccAmpCoV 0.413867
tremorPcRelVar 0.891941
tremorPcX -0.180957
tremorPcY -0.983491

ZigZag Offset Segment 1

Duration 27.0 s, Accuracy Estimate 0.053 (lower is better)

ZigZag Offset Segment 2

Duration 29.96 s, Accuracy Estimate 0.069 (lower is better)

ZigZag Offset Segment 3

Duration 24.4 s, Accuracy Estimate 0.048 (lower is better)

ZigZag Offset Segment 4

Duration 28.36 s, Accuracy Estimate 0.071 (lower is better)

ZigZag Offset Segment 5

Duration 22.0 s, Accuracy Estimate 0.053 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.79}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.53}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.07966849716035584}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9444588622388082}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.44192353540889495}